Adaptive medicine: human psychophysiological adaptation strategy to a critically altered environment

In the context of growing contradictions between the state of the critically changed socio - natural environment and the possibilities of modern man to adapt to new rapidly emerging challenges and stressors, there is a growing need to search for new techniques for expanding human “internal limits” (A. Peccei), his adaptive potential. Modern scientific data confirming the possibility and necessity of applying the principles and technologies of an interdisciplinary direction - adaptation medicine in life of every person of any age and health condition are substantiated in the paper. The accumulated research data from the moment of G. Selye’s concept up to modern time proves the effectiveness of the phenomenon of controlled long - term cross - adaptation as a preventive and therapeutic measure capable of preparing and protecting the body from the damaging effects of the environment. The problem of individual dosing procedures based on the principles of adaptive medicine, as the main factor limiting their widespread use, is discussed. Criteria for assessing the adequacy of the ongoing adaptive changes should be based on a detailed understanding of the underlying mechanisms at different levels: molecular, cellular, organismic, social, and be considered together, from a systematic approach.