Activity of lipid peroxidation and condition of lens antioxidant system on the experimental cataract against the background of local antioxidants

In the present research we have made a comparative analysis of the influence of a local application of direct synthetic antioxidant ionol, and natural biological antioxidant apicomposition on the lens free-radical status during cataract formation. Apicomposition consisted of honey, native royal jelly and propolis. Experimental cataract was induced by a single injection of diquat dibromide water solution into the vitreous body. The dynamics of the cataract process and the severity of oxidative stress, total antioxidant system capacity and activity of antioxidant enzymes in the lens were determined. It is shown that instillation into the conjunctival cavity Ionol solution led to regression (50%) and stabilization (33 %) lens opacities, significant reduction the activity of lipid peroxidation, normalization activity of glutathione-dependent antioxidant enzymes. Clinical and biochemical effects of apicomposition were also quite pronounced, but more effective in all parameters was ionol. Thus, the findings suggest the feasibility of using synthetic and natural antioxidants for pathogenic cataract treatment.