Analysis of associations of the level of personal anxiety with allelic variations of metabolic genes

The study is devoted to the identification of genetic markers associated with increased personal anxiety among 119 mentally healthy people, mainly of Russian nationality, living in the European part of Russia. The level of personal anxiety was determined using the Spielberger-Khanin questionnaire and self-questioning. Gene variants COMT rs4633, rs4680, APOE rs429358, rs7412, CBS rs234706, rs4920037, MTHFR rs1801131, rs1801133, NOS3 rs1800779, and VDR rs2228570 were determined using PCR-RDRF analysis and Real-Time PCR. Statistical processing of the results was carried out using a two-way accurate Fisher test, with a threshold significance level of p value <0.05. An association with increased anxiety was found for APOE rs7412 C/T (p=0.02), APOE e2/e3 (p=0.04), CBS rs4920037 A/A (p=0.019), NOS3 rs1800779A/A (p=0.008), VDR rs2228570 G/G (p=0.034) with moderate and low anxiety are associated: NOS3 rs1800779A/G (p=0.01), APOE e3/e4 (p=0.035).