Molecular and biological аspects of platelet-rich plasma therapies

Biological therapies have attracted more and more attention in recent decades. Knowledge of the basic biological mechanisms involved in tissue response to injury should inform management of healing. Approaches to influence healing may need to integrate multiple cell types and large signaling networks that are necessary for the dynamic communication between cells. To date, in medicine, widespread therapies based on the use of autologous blood plasma (ABP). In this study, a biological analysis of platelet-rich plasma was performed. obtained using tubes for ABP-therapy of two types. In the first group, test tubes were used to obtain PRP, in the second to obtain ACP. The study showed that when choosing tubes for PRP therapy, it is important to take into account the centrifugation mode and the plasma selection system, preferring closed systems that allow to obtain pure ABP, preserve sterility and reduce the risks of contamination of biomaterial with a minimum number of manipulations. In particular, the therapy of inflammatory nosologies requires the use of PRP, which may determine the possibility of correcting the local immune status. In cavity operations in ophthalmology, it is advisable to use ACP, which has a low response from the immune system. The main role of APC in this case tamponade tissue defect due to the properties of the material used. Identifyingwhich molecular mechanisms are more or less important during the course of healing andclarifying the molecular basis for differences in the healing response across patients willcontinue to be the priority to tailor PRP therapies for particular sports injuries.