Analysis of polymorphisms RS28363170 gene of the dopamine transporter SLC6A3 and RS4646984 gene of the dopamine receptor DRD4 in persons with different depression level

Depression has now become a global mental health problem. Changes in the activity of Central dopaminergic mechanisms play a significant role in the emergence and development of depression, which is confirmed by the detection of metabolic disorders of biogenic amines in various types of depression. Therefore, the analysis of the frequency distribution of genotypes and alleles by polymorphic loci of genes of dopamine carrier SLC6A3 and dopamine receptor DRD4 was carried out.