The incidence of mutation BRCA1 5382insC in ovarian cancer patients in siberian region, Russia

Insertion 5382insC in BRCA1 gene is the most frequent mutation associated with high risk of ovarian cancer in women of the East Europe population. Genotyping of 97 DNA samples of patients with the diagnosis «ovarian cancer» was carried out. From the total number of patients 4 women (4,1 %) had mutation 5382insC in a heterozygote state. Hereditary form of ovarian cancer (the family history of the given disease) has been fixed only in one case. Identification of the given mutation in healthy women is important for the early diagnostics of ovarian and breast cancers, whereas among patients it is important for the personalized treatment