Antithrombogenic vessel wall activity in women with climacteric myocardiodystrophy during the period of peri- and postmenopause

Rationale: Climacteric myocardiodystrophy (CM) is a disease that not only leads to the quality of life worsening in females, but also has socioeconomic implications as a disease promoting the decrease in female workability. Whether changes of antithrombogenic vessel wall activity (ATVWA) occur in the peri- and postmenopausal period in this patient category remains unclear. Study objective: analysis of antithrombogenic vessel wall activity in the peri- and postmenopausal period of females with climacteric myocardiodystrophy. Materials and methods: The total number of females with CM was 330. Antithrombogenic vessel wall activity was evaluated based on anti-aggregation, anticoagulant, and fibrinolytic activity of vessel walls that were determined according to the method of M.V. Baluda. Results: Out of 330 patients suffering from climacteric myocardiodystrophy, decreased anti-aggregation, anticoagulant, and fibrinolytic activity of the vessel wall was found in 199 women. Antithrombogenic vessel wall activity was normal in 131 females. With that, the decrease was statistically significant (p