Association of severity of acute pancreatitis with polymorphisms of the ITGA2 gene (C807T)

The article presents the results of a clinical study of 68 patients with acute pancreatitis, who were divided into 2 groups according to severity upon hospitalization. The activity of the coagulation-lytic system of blood, the state of microcirculation, and the intensification of membrane lipid peroxidation were determined. Genetic study of platelet receptor genes (C807T ITGA2) was carried out using real-time polymerase chain reaction. It was found that oxidative stress, microcirculation disorders, and imbalance of blood coagulation components (hypercoagulation and hypofibrinolysis) play a special role in the development of acute pancreatitis. These deviations were associated with the severity of patients: in mild cases, they were reversible by the 3rd day, and in severe cases, they were persistent. An association was found between the severity of acute pancreatitis and ITGA2 gene polymorphisms (C807T). With the normal allele C807C of the ITGA2 gene, homeostatic disturbances were minimal, and with the mutant allele, they were maximal.