Circadian epigenetics of Alzheimer's disease

Interdisciplinary and interdepartmental interaction, gerontoneurological and gerontopsychiatric combined neurorehabilitation of Alzheimer’s disease (AD), the combination of healthy lifestyle, physical activity, functional nutrition, circadian rhythms and maintenance of the activity of “cognitive brain” on the 4P medicine platform will create a medical and economic basis for individual and regional increase in human life expectancy. The paper shows that the presence of the specific mutations in the genes of predisposition to AD increases the risk of developing the disease. Using, alongside with hybrid and combined methods of managing the “cognitive brain”, IT-technologies and new-generation automatic analysis of full-genome sequencing in modern medical-diagnostic process improves the quality of medical care. The study of genetic and epigenetic features of neurodegeneration will allow to introduce more effective methods of treatment of age-dependent cognitive disorders into clinical practice. Circadian epigenetics and modern chronomedicine are innovative fields of science that study the complex influence of cosmic, biophysical, biological, genetic, medical and social factors on the human body.