Circadian stress of homo sapiens: new neurophysiological, neuroendocrine and psychoneuroimmune mechanisms

Circadian stress causes dysregulation of brain Homo sapiens software followed by impairment of the cognitive and visceral brains. The body’s circadian rhythms are programmed with a system of circadian genes. Circadian clock and circadian system - are the biophysical and biochemical regulators of immune protection. Circadian synchronization system is an evolutionary software product of biocomputer for survival and preparation of the organism for expected cyclic challenges, different epigenetic orientation. Understanding the temporal relationship between stressors and stress reactions is critical to understanding the molecular foundations of the physiology and pathogenesis of the disease. Chronic stress and circadian mismatch trigger a cascade of failures in the functioning of neurophysiological, neuroendocrine, and psychoneuroimmune mechanisms. Epigenetic loading and allostatic overload reduce both the body’s overall workability and its physical, occupational, and cognitive components...