Cytokine profile of experimental animals when using intramedullary implants with biocomposition coating

Today, domestic and foreign scientists pay great attention to the study of the functions of cells of the immune system that regulate the mechanism of osteogenesis.The significant value of anti-inflammatory cytokines (interleukin-1, interleukin-6, tumor necrosis alpha factor, vascular endothelial growth factor) in the regulation of the mechanism of reparative osteogenesis has been determined. The aim of the study to examine the cytokine profile (IL-1ß, IL-6, TNF-α, VEGF) of dog blood against the background of the use of the developed biocomposition coating of implants after experimental modeling of corticotomy of the radius in the middle third of its diaphysis was set by a group of authors. The blood serum of the experimental animals (dogs) was the material for measuring the level of cytokines IL-1ß (interleukin 1 beta), IL-6, TNF-α (tumor necrosis factor), VEGF (vascular endothelial growth factor). Blood sampling for the study was performed from the forearm vein before the operation, on the 3rd, 7th, 14th, 30th, 45th and 60th days after it. As a result of the study of the cytokine profile using 3.5% and 5% biocomposition coating of implants, to accelerate consolidation, the level of IL-1ß (interleukin 1 beta), IL-6 (interleukin 6) and TNF-α, between the experimental groups, no significant difference was revealed. The study of the cytokine profile of the blood of dogs when using a biocomposition coating of implants to control the effectiveness and accelerate the consolidation of bone tissue in small unproductive animals, which in turn provides prerequisites for the introduction of this coating into practice for farm animals and in humane medicine due to the similarity of the process of bone formation.