Cytokine profile in patients with simple chronic bronchitis and dysplastic changes in bronchial epithelium

The level of pro-and anti-inflammatory cytokines in bronchial alveolar lavage was determined in 110 patients with simple chronic bronchitis and bronchial epithelium dysplasia. The analysis showed that cytokines had the anti-inflammatory regulatory effect on the surface of bronchus mucosa. The most pronounced changes in lacal production of cytokines were observed in patients with bronchial catarrh and grade I-II dysplasia of bronchial epithelium. Cytokine unbalance was observed in patients with catarrhalsclerosal bronchitis and grade II-III grade dysplasia of bronchial epithelium, however the differences from the control values were inconsiderable.