Dynamics of changes of lipid peroxidation transfusion of blood substitutes on the background hypovolemic shoc

As noted in previous studies, the intensity of lipid peroxidation (LP) is dependent on the functional state of organs and tissues, the impact of such factors as the postnatal development of the body, adaptation to extreme factors - ionizing radiation, breach of the oxygen supply, poisoning, change of endocrine status of the organism, stress greatly increase the LP. Increased lipid peroxidation causes structural and functional modifications in the cell membranes, compounding pathological processes. We began the study of the lipid peroxidation during the hypovolemic shock with the study of the accumulation of lipid peroxidation products in different brain structures. The accumulation of hydro peroxides (HP), malondialdehyde (MD) in the cerebellum, midbrain, medulla oblongata, sensory-motor and visual areas of the cerebral cortex were investigated during the 16 hours after hypovolemic shock. Results obtained in a variety of CNS structures show that during hypovolemic shock the greatest deviation in the level of hydro peroxides posterior lobe is observed in cerebral cortex and medulla. The table shows that the change in the content of malondialdehyde in various structures of the central nervous system is slightly different from what we have seen in the study of changes in the content of hydro peroxide in the background of hypovolemic shock. To sum up the results of the study, we can conclude that the transfusion of blood substitutes on the background of hypovolemic shock and delays the activation and deepening of the generalization of lipid peroxidation in the late hours of experience in hypovolemic shock.