Dynamics of the cellular component of the connective tissue capsule during implantation of a super-light polypropylene-polyvinylidene fluoride endoprosthesis (experimental study)

Objective: to study the effect of platelet-enriched autoplasm on the dynamics of the cellular component of the connective tissue capsule during implantation of a super-light polypropelin-polyvinylidene fluoride endoprosthesis. An experimental study was performed on 50 Chinchilla rabbits. 2 equal groups of 25 individuals each were formed. ln both groups, a super-lightweight polyvinylidene fluoride endoprosthesis was implanted on anterior abdominal wall aponeurosis. ln the 1st (main) group, platelet-enriched autoplasm was injected under the prosthesis, and in the 2nd (control) group, it was not injected. Histological and immunohistochemical studies with monoclonal antibodies to the marker of cell proliferation Ki-67 were carried out. The dynamics of the capsule cell wall thickness, inflammatory and fibroblastic reactions, and proliferation index were evaluated. Results: After the introduction of autoplasm, there was a statistically significant increase in the thickness of the capsule at the end of the experiment by 2.8 times, a decrease in the severity of the inflammatory reaction on day 7 by 1.5 times, an increase in the fibroplastic reaction from 1.9 to 2.3 times, an increase in the proliferative activity of cells from 1.3 to 2.7 times at various periods of the experiment. Conclusion: The administration of plasma enriched with platelets increases the proliferative activity of connective tissue cells.