Dynamics of cognitive impairments when cortexin is included in the therapy algorithm for patients with alcohol dependence who have undergone a generalized tonic-clonic seizure at the time of hospitalization

Background. The effects of cortexin in chronic fatigue syndrome, traumatic brain disease and traumatic brain injury, resistant paranoid schizophrenia, psychosomatic disorders in liquidators of radiation accidents, and various types of strokes are described. Optimization of the treatment process with the use of cortexin contributes to the recovery and stabilization of higher cerebral, cognitive and motor functions, activation of dopamine metabolism. Objective: to study the dynamics of cognitive disorders when cortexin is included in the treatment regimen for patients with alcohol dependence who have undergone a generalized tonic-clonic seizure at the time of hospitalization. Materials and Methods: the study included 40 patients aged 23 to 60 years, with alcohol dependence diagnosed according to ICD-10 (F10.2), who had a generalized tonic-clonic seizure (G40.6), randomized into two groups. The main group consisted of 20 individuals, all of them were prescribed Cortexin at a dose of 10 mg for 10 days. The comparison group included 20 individuals who received standard treatment (detoxification and nootropic therapy, vitamin therapy). The Mini-Mental Status Scale (MMSE) was used to assess cognitive impairment before and after treatment. Results. The introduction of Cortexin with an neuroprotective effect, into the treatment regimen for cognitive disorders in alcohol dependence, improves cognitive functions: the mean MMSE score before and after treatment with Cortexin statistically significantly (p function show_eabstract() { $('#eabstract1').hide(); $('#eabstract2').show(); $('#eabstract_expand').hide(); }