Pharmacoepidemiological analysis of the use of oral hypoglycemic preparations: factors affecting the effectiveness of pharmacotherapy for type 2 diabetes mellitus

As a result of the pharmacoepidemiological study, factors have been established that make it possible to increase the effectiveness of hypoglycemic therapy and the compliance of patients with diabetes mellitus in the Kyrgyzstan. The structure of the prescribed oral hypoglycemic agents was investigated; the assessment, according to the results of the questionnaire of patients, was given of the effectiveness of the hypoglycemic therapy they received, as well as the level of its compliance with modern medical guidelines for the diagnosis and treatment of diabetes. At the time of filling out the questionnaire, only 44% of respondents had a target fasting glucose level (≤7 mmol/l). According to the data obtained, it can be concluded that in real clinical practice, the effectiveness of diabetes treatment remains low. We have obtained data that 47.8% of patients with diabetes are not adherent to treatment, which may also contribute to a rather low percentage of patients among the respondents who have reached the target blood glucose level. As for the use of drugs, the analysis of the data showed that the majority of patients (62.81%) receive monotherapy with oral hypoglycemic agents. According to the analysis, metformin is the most commonly used drug among the oral hypoglycemic agents. It is accepted by 60.1% of the respondents. Most diabetic patients spend 1000 som or more per month on oral hypoglycemic agents. Taking into account the cost of living in the country, it can be concluded that the acquisition of oral hypoglycemic agents significantly affects the budget of citizens and that there are problems with the economic availability of oral hypoglycemic agents. The results of our research indicate the insufficient effectiveness of the treatment and prophylactic measures for type 2 diabetes in our country, requiring more active work in this direction. The work was carried out in the design of a simple one-step prospective descriptive epidemiological study within the framework of a pharmacoepidemiological study.