Enzymes of energy metabolism in brain and chronic stress

The development of changes in the activity of creatinkinase, aldolase and succinatdehydrogenase in brain cells under 30-day long stress induced by isolation and violated diurnal cycle has been studied. It was shown that these enzymes heterogeneously responded to 30-day long stress. Particular sensitivity was recorded in the case of succinatedehydrogenase, which showed the decline of activity in various sections of the brain by 60-80% on average. Unlike succinatedehydrogenase, aldolase activity increased on the 10th day of stress and then declined. Similar results were observed in relation to phosphokinase activity.