Hematological coefficients of systemic inflammation as potential biomarkers of suicide

Suicide is one of the leading causes of death throughout the world, however, despite the prevalence and high social significance of this problem, effective methods for diagnosing, predicting and preventing suicidal behavior have not yet been developed. The aim of this review is to systematize data on the role of inflammatory processes in the formation of suicidal risk and the possibilities of using inflammatory markers for the purpose of its prevention. The focus is on hematological ratios of systemic inflammation (neutrophil-lymphocyte (NLR), monocyte-lymphocyte (MLR) and platelet-lymphocyte (PLR) ratios, as well as systemic immune inflammation indices (SII, platelet count x neutrophil / lymphocyte count) and systemic inflammatory response (SIRI, neutrophil count x monocyte/lymphocyte count)) as easy-to-use and cost-effective indicators of a complete blood count. These ratios appear to be a promising new approach for suicide prediction and prevention. The literature analysis indicates that due to the complexity of this process, as well as the fact of the presence of an underlying mental disorder that contributes to the inflammatory process, an integrated approach to studying the role of neuroinflammation in suicidality is advisable, taking into account both biological and stress factors. environmental factors.