Histopatomorphological changes of internal organs of guinea pigs during the introduction of antituberculosis preparation KIM-M2

The research objective was studying the dynamics of histomorphological changes in lymph nodes, spleens, lungs and liver of the guinea pigs subjected to introduction of antitubercular preparation of KIM-M2 after the infection with virulent culture of M. of bovis. For experimental infection of guinea pigs virulent culture of M. of bovis strain 8 received from a bioresource collection of cultures of microorganisms of department of veterinary science of FSBRI"Omsk ARC" was used Experimental animals were supported in conditions of a specialized vivarium for carrying out the researches with infectious agent. In 45 days after the nfection of animals brought out of experiment by a decapitation. For histological research autoptata of lungs, spleens, liver and inguinal lymph nodes were taken. Autoptata were concluded in cartridges and were placed in 10 % solution of neutral formalin on phosphatic buffer. The preparation of the material was carried out at MICROM STR-120 station. Filling by paraffin was carried out at filling station MICROM ES-350...