Identification of sensitive to the influence of carbon monoxide molecular targets responsible for G1 phase control of cellular cycle

The influence of CO-releasing compound CORM-2 on the key molecules - regulatirs of the cellular cycle G1 phase (cyclin D1, retinoblastoma protein, protein-inhibitor р21) of Jurkat line has been analyzed in the given paper. It is shown that CO donor causes the delay of cells in G1 of the cellular cycle against the background of increasing the content of cyclin D1 and phosphorylated form Rb. Antiproliferative effect of carbon monoxide was not mediated by increasing the content of protein р21.