Idiopathic thrombocytopenic purple, issues of pathogenesis

Anotation. Idiopathic thrombocytopenic purpura (ITP) is a hemorrhagic diathesis caused by a shortened lifespan of platelets and a decrease in their number as a result of destruction by antiplatelet antibodies. The pathogenesis of ITP is complex and not definitively deciphered. Platelet-labeled studies have shown that all patients with ITP have a sharply shortened platelet lifespan to a few hours instead of the normal 7-10 days.