Immunological mechanisms of skin protection

The review highlights the state of the skin as an organ of immunogenesis due to the presence in it of various populations of immunocompetent cells: T-, B-lymphocytes, NK- and dendritic cells, which are so important for the development of the immune response. This gives the skin the opportunity to perform a number of physiological functions important for the body: recognition of antigenic material and its elimination, extrathymic differentiation of immature cells into T-lymphocytes, immunological surveillance of tumor cells and others. The variety of cells included in the immune system of the skin, as well as the diversity of their functions explain the fact that at the skin level, all types of immunopathological syndromes (immunodeficiency, autoimmune, allergic, lymphoproliferative) can occur.