Interferon-tau and formation of pregnancy in cows

Coordinated action of steroid and peptide hormones and interferons ensure the formation of pregnancy and embryo-fetal development in cows. A special class of such interferons is interferon-tau (INFT) which is synthesized by embryo trophoblast cells. This interferon is responsible for preserving the progesterone synthesis by the ovary yellow body and embryo implantation. This paper is the first in which we report a significance of INFT under impaired embryonic development and data on evaluation of biological and clinical efficacy of bovine recombinant INFT administered to cows after artificial insemination. The aim of this work was to study the dynamics of the blood content of INFT and progesterone (P4) during early pregnancy of Black-and-White cows ( Bos taurus taurus ) and to identify the possibility of using a bovine recombinant INFT preparation to prevent embryonic losses and to increase the effectiveness of insemination. Recombinant INFT was obtained at the Belarusian State University (V...