The drosophila adaptation mechanisms to benzotriasole

The Drosophila adaptation mechanisms to sub-lethal benzotriasole doses are investigates. It is showed that benzotriasole induces dominant and recessive lethal mutations both in non-toxic dose (0,1 mg/ml) and LD50 dose. Under constant benzotriasole action in LD50 dose during 5 generations the mortality decrease in all ontogenesis stages and fertility rehabilitation. The experiments on prolonged and short pre-adaptation to non-toxic dose to mutagen action of LD50 dose showed the difference in mutagen answer of Drosophila males and females. It is showed that adaptation appearance to tested xenobiotic is connected with organisms selection on highly active resistance during gametogenesis period