The studies of first antiplatelet drugs: acetylsalicylic acid, ticlopidine and clopidogrel

Antiplatelet agents significantly reduced mortality and morbidity of coronary heart disease, cerebrovascular disease and peripheral artery disease. Therefore, antiplatelet agents are an important part of optimal drug therapy in such patients. Acetyl-salicylic acid remains the most commonly recommended drug, especially for the prevention of thrombotic complications. Clopidogrel is an alternative to acetylsalicylic acid, as well as an important component of dual antiplatelet therapy for balloon angioplasty and stenting. Ticlopidine is not used in practice according to the guidelines due to numerous side effects and the development of safer and more effective P2Y12 antagonists.