Change in the activity of pentoxyplin under the action of a pulse magnetic field depending on the drug composition

According to the results of the study, it was found that irradiation of the tabletted preparation of pentoxifylline leads to an increase in its antiaggregatory activity. The aim of this work is to study the effect of a pulsed magnetic field of high intensity on the antiaggregatory activity of the pure substance of petoxifylline. When exposed to a pulsed magnetic field on the pure substance of pentoxifylline (without the presence of excipients), changes in the antiaggregatory activity of the drug were not detected. Irradiation with a pulsed magnetic field was carried out on an MIU-15 setup at various magnetic field strengths with single-turn and multi-turn inductors with the number of pulses n = 1. The authors put forward a hypothesis that excipients in a tabletted medicinal product affect the change in biological activity after exposure to the drug by a pulsed magnetic field of high intensity. The study of the pure substance of pentoxifylline for antiaggregatory activity was carried out on an AT-02 platelet aggregation analyzer. Control samples of the medicinal product were not exposed to the magnetic field. It is assumed that the presence of excipients in the tablet form of pentoxifylline after exposure to a pulsed magnetic field can cause a change in the conformation of the drug molecule. In addition, a transition from one conformation to another is possible due to abrupt changes in properties, i.e. when exposed to a high-intensity magnetic field. An antiplatelet agent with excipients, being in a magnetic field, goes into a more active state, after which it retains it for some time, in which an increase in pharmacological activity is manifested.