Features of any enzyme changes in response to the introduction of metilphosphonic acid to males of laboratory mice

It is shown that after intramuscular introduction to males of laboratory mice methylphosphonic acid (MPA) in high (50, 2 mg/kg of animal weight) and low (10-12, 10-15, 10-18 mg/kg) doses over 3 days activity of a cholinesterase and aspartate - and alaninaminotranspherases blood plasma decreased on the average for 20-40% (in contrast to the average doses MPA, whose introduction little effect on the activity of these enzymes); 12 weeks after the introduction of low (10-15 mg/kg) dose of MPA activity enzymes increased by 20-70%. Oral administration of the MPA did not lead to significant changes in the activity of these enzymes.