Study of inhibin B level and anti-Mullerian hormone in experimental autoimmune oophoritis

The aim of the study was to assess the dynamics of the concentration of inhibin B and antiMullerian hormone (AMH) at stages of the autoimmune destruction of ovaries in experiments on mature females of white rats with the original model of autoimmune oophoritis (AO). The study was performed using histological and histochemical studies of ovaries and determination of the concentration of antiovarian antibodies (AOA), inhibin B and AMH in serum by enzyme immunoassay. The final formation of the AO occurred on the 30th day of the experiment, which was confirmed by significant increase of the concentration of AOA. The increase of the specific volume of primary and secondary follicles to the 60th day of the experiment was accompanied by an increase in the concentration of inhibin B, caused by selective theca cell destruction of growing follicles. Change in concentration of AMH was observed in different periods of the experiment.