Synergy effect of endogenic antimicrobial and low-molecular placentary peptides in the composition of niosomal gel in treatment of burns infected by antibiotic-resistant microbe

In experiments on rats, a model of an infected burn was created to study the effectiveness of a combination of isolated endogenous antimicrobial and low molecular weight placental peptides in a niosomal gel. In the experimental group, when applying niosomal gel with antimicrobial peptides, the linear rate of wound healing was (0,0272 ± 0,0094) mm / day, which significantly exceeded the indicators of the control group. The calculation of the percentage rate of wound healing correlated with the results of the relative loss of wound area: niosomal gel with antimicrobial peptides accelerated wound regeneration. This tendency was especially noted in the period from 9 to 16 days of the experiment with burns infected with Staphylococcus aureus. Based on the studies carried out in an experiment on rats, a conclusion was made about the effectiveness of niosomal gel with endogenous antimicrobial and low molecular weight placental peptides when applied twice to burns complicated by antibiotic-resistant microflora.