Clinical and metabolic characteristics of androgenic deficiency in patients with type 2 diabetes mellitus

Resume: Diabetes mellitus (DM) is a significant medical and social problem. In 2010, according to forecasts, about 215 million people with type 2 diabetes will live on our planet. Type 2 diabetes is a heterogeneous disease that develops as a result of a combination of congenital and acquired factors, in the mechanism of its development characterized by a combination of two fundamental pathophysiological defects: insulin resistance and dysfunction of b-cells of the pancreas. The development of type 2 diabetes begins mainly after 40 years. It is known that men experience a gradual decrease in testosterone levels with age, which leads to age-related hypogonadism. The simultaneous development of diabetes mellitus and age-related hypogonadism, accompanied by a decrease in the secretion of both total and free testosterone, has been noted in numerous studies [5]. At the same time, many researchers have found a relationship between the level of total testosterone in plasma and the development of type 2 diabetes.