Clinical, morphological and molecular predictors of metastatic regional lymph node involvement in breast cancer patients

Background. The article presents the results of our study aimed to identify predictors of metastatic regional lymph node involvement based on the biological characteristics of the primary tumor. Materials and methods. The study involved 200 female patients with histologically verified unicentric invasive breast cancer (BC) T1-4N0-3M0 who were treated in the state healthcare institution Regional Clinical Cancer Center of Ulyanovsk between 2012 and 2015. Clinical, morphological and molecular parameters of the tumor were analyzed. Results. A unifactorial statistical analysis has shown that the size of the primary tumor node (p = 0.027), histological variant (p