Markers of immune regulation in children exposured to aluminum

The study of immune regulation indicators in the children's population living at the industrial aluminum pollution area revealed that against the background of an increased level of metal in the blood, by 2.18 times regarding the comparison group, there was a decrease of the phagocytic activity of immune cells according to the “phagocytic number” in 85.2 % of children relative to the physiological norm, a reduction in the content of serum immunoglobulins IgG, IgM and IgA by 1.48, 1.30 and 1.21 times, respectively, relative to the comparison group. At the same time, there was an increase in the relative number of regulatory CD4+CD25+CD127--lymphocytes in 80.0% of the observation group, when compared with reference levels, a decrease in the number of CD16+CD56+-lymphocytes regarding the comparison group, on an average by 1.72-1.92 times, and the content of CD19+-cells by 1.29 times, as well as the excess of the reference values of specific sensitization in the concentration of specific antibodies IgG to aluminum in 66.4% of the children’s population, and by 1.86 times relative to the comparison group. The studied features of immune reactivity may be used as indicator criteria for the health state of the population associated with the functioning of adaptation mechanisms under aluminum exposure conditions.