Markers of the pathogenesis of acute coronary syndrome in patients with type 2 diabetes mellitus in predicting distant adverse outcome

Prediction of adverse cardiovascular events after acute coronary syndrome (ACS) is a challenge, including in patients with diabetes mellitus. Objective: to evaluate the role of markers of inflammation, endothelial dysfunction, the destabilization of atherosclerotic plaques and thrombosis in the prediction of adverse events and create a risk assessment model. Materials and Methods: the study was conducted among patients with myocardial infarction, unstable angina with concomitant type 2 diabetes and control groups. Patients in the blood serum C-reactive protein (CRP), soluble CD40 ligand (sCD40L), angiotensin II (ATII), natriuretic propeptide с - type (CNP), interleukin - 1 ß, 4, 6, 10, (IL1 ß, IL4, IL6, IL10), tumor necrosis factor alpha (TNFa). Results: ln patients with acute coronary syndrome showed improvement of all parameters when compared to the control. The impact of all markers on prognosis of acute coronary syndrome was statistically significant, on the basis of which was created a model predicting the risk of an adverse outcome after myocardial ACS. Conclusions: this model has shown high sensitivity and specificity in predicting adverse outcome of ACS with concomitant type 2 diabetes.