Mechanisms of blood system regulation under the influence of hemostimulators in conditions of myelosupression

The effect of various hemopoiesis stimulators on the granulocytic stem-cell recovery under the condition of cyclophosphane-induced myelosupression was studied. Cultural and morphological methods of studying the hemopoietic cells and hemopoiesis-induced microenvironment were used. Granulocytic colony-stimulating factor was shown to stimulate proliferation and differentiation of hemopoietic cells. Pantogematogen enhanced proliferation of granulocytes due to activation of regulatory systems. D-glucuronic acid and glyciram normalized structural-functional organization of bone marrow producing the intensive maturation of colony-forming units.