Melatonin: neurophysiological and neuroendocrine aspects

Optimization of neurobiological and chronomedicine processes possible with the development of circadian melatonin and ensuring its long-term concentration in the human body. Individual combined (drug and non-drug) intervention in the circadian axis ‘microbiota-intestine-brain’ with the help of daily consumption of functional foods, has a positive effect on cognitive and mental health. Introduction of research results N. P. Romanchuk (2010, 2013, 2016, 2017), it allows you to restore the functioning of the circadian system of man, normalize the level and concentration of melatonin in the body, to regulate sleep and wakefulness, to control neuroplasticity, to prevent cognitive impairment, to activate their own circadian rhythms and their synchronization with the environment, through the use of multimodal schemes to increase the circadian level of the hormone melatonin in the human blood: circadian glasses, functional nutrition and physical activity. Further study of polymodality neural networks with neurophysiological and neuroendocrine mechanisms in neurobiological and chronomedicine the processes of functioning ‘cognitive’ and ‘visceral’ brain, will enable you to save sufficient neuroplasticity to increase cognitive reserve in the brain. To normalize the circadian rhythms of a person, a multimodal scheme for increasing the circadian level of the hormone melatonin in the human blood is proposed: circadian glasses, functional nutrition and physical activity.