Metabolic changes in cows during mastitis and their dynamics in sorption therapy background

The aim of the study is to evaluate the effect of enterosorbent, when included in the protocol of standard therapy for mastitis in cows, on blood biochemical parameters. Three groups of cows with a similar pathology were formed: a control (standard therapy) group and two experimental ones. Blood was obtained in the morning before feeding, serum was analyzed on biochemical analyzers. Standard therapy included the introduction of a suspension of Hamaret through the nipple canal and a 10 % solution of the drug "Marboflocin" subcutaneously once a day for 5 days. Experienced groups 2 and 3 received an oral enterosorbent based on polymethylsiloxane polyhydrate at a dose of 0.2 and 0.5 mg/kg of live weight, respectively. The drug was administered 2 hours after the last feeding. Before treatment, cows showed hyperglycemia, hyperproteinemia, a decrease in the protein coefficient, and increased activity of alkaline phosphatase. Standard therapy led to nonsignificant changes in total protein and protein fractions, creatinine and total bilirubin, increased urea, decreased glucose and direct bilirubin. In the 2nd and 3rd groups, there was a decrease in cholesterol, direct bilirubin, total protein, an increase in the albumin-globulin coefficient, which was accompanied by a decrease in the activity of alkaline phosphatase. The cows of the 2nd group showed an increase in AST and a tendency to a decrease in ALT, in the 3rd group - an insignificant change in AST and a decrease in ALT. It was found that it is most effective to inject enterosorbent at a dose of 0.5 mg/kg of live weight 2 hours after feeding. This dose helps to reduce total protein by 8.23 %; direct bilirubin – by 71.28; glucose - by 66.81; cholesterol - by 31.08; ALT - by 18.57; alkaline phosphatase – by 66.70 % and an increase in the albumin-globulin coefficient to 0.89.