Metabolic shifts in subjects with potential risk of primary osteoarthritis

The Aim of the study was to estimate metabolic disorders in subjects with potential risk of primary knee osteoarthri-tis development. Material and Methods. The study included 27 patients: 10 men (37%), 17 women (63%) aged from 33 to 68 years, and 20 healthy people (8 men and 12 women). Traditional biochemical indexes characterizing certain metabolic aspects (total protein, urea, cholesterol, glucose, uric acid, amylase and bilirubin) were studied alongside with the assessment of articular cartilage state by the level of COMP (cartilage oligometric matrix protein), malondial-dehyde and ceruloplasmin. Results. In the course of our investigation we observed elevated COMP (Me=871,4 (792,2; 912,5)), malondialdehyde (Me=5,1 (4,7; 5,5)) and ceruloplasmin (Me=48,4 (41,2; 55,4)) levels. Conclusion. Negative metabolic shifts in the form of cartilage tissue metabolic disorders, activated lipid peroxidation and relative failure of body antioxidant system were observed in patients with potentially high risk of knee osteoarthritis without clinical manifestations of the disease.