Metabolic syndrome, interraction with endometrial carcinogenesis

The review presents the modern concept on the relationship between metabolic syndrome and endometrial cancer. Metabolic syndrome is one of the main risk factors for cardio-vascular diseases, carbohydrate metabolism injury and reproductive system pathology. The incidence of endometrial cancer is 2-3 times more frequent with the evidence of metabolic syndrome. It is caused by aggravation of insulinoresistance, increase in androgen production by ovaries, and formation of stable anovulation resulting in progression of pathological changes in the endometrium and accumulation of carbohydrate metabolic products with anti-proliferative action. The role of obesity as a risk factor for development of uterine body cancer is more significant in reproductive age than in menopause.