Gut microbiota: a new regulator of cardiovascular function

In studies Romanchuk N. P. from invention in 2010 (A method for producing a cereal component for an instant food product and a method for producing a functional instant food product. RF patent for invention №2423873, consisting in increasing the preventive effect on the human body through the introduction of vital food substances into a functional food product to suppress free radical activity, invasive detoxification of the human body, optimizing neurogenic regulation of vascular tone in arterial hypertension and restoring reproductive functions in males and females by optimizing the quality structure of product components), to the present (https://doi.org/10.33619/2414-2948/58/14) it has been shown that a new managed healthy biomicrobiota and personalized functional and balanced nutrition of the “brain and microbiota” is a long-term medical program of the patient, which allows the combined use of nutritional epigenetics and pharmaceuticals, and most importantly the prevention of polypharmacy. The main engine of human longevity is when microbiological memory remains stable, and the diet of functional (healthy) dietary nutrition and the structure of healthy biomicrobiota function almost unchanged. The human microbiome is a collection of all microbes that inhabit the body. The human gut microbiome is a unique collection of microorganisms that affect a number of important processes: from metabolic and immune to cognitive, and deviation of its composition from the norm leads to the development of various pathological conditions. Harmful changes in the composition or number of gut bacteria, commonly referred to as intestinal dysbacteriosis, have been associated with the development and progression of numerous diseases, including cardiovascular (CVD) diseases. Most CVD risk factors, including aging, obesity, certain dietary patterns, and sedentary lifestyles, have been shown to cause bowel dysbiosis. Dysbacteriosis is associated with gut inflammation and reduced gut barrier integrity, which in turn increases levels of circulating structural components of bacteria and microbial metabolites that may contribute to CVD development. The purpose of the present review is to summarize available data on the role of the gut microbiome in the regulation of cardiovascular function and pathological processes. Particular attention is paid to dietary-related microbiome changes, as well as cellular mechanisms by which the microbiome can alter CVD risk.