Microfluidic chips with integrated nanoscale structures for biological objects fixation

Hhydrodynamic trap to capture particles in a microfluidic chip with a network of parallel nanoscale channels and the U-trap with nanoscale channels were developed and studied. The simulation of liquid mass transfer process in the trap was performed. A nanoscale structures for traps was made by the method of focused ion beam. The prototype microfluidic chips with traps for high-resolution microscopy were obtained. Experimental studies on the movement of particles and liquid flows in channels of microchips confirm the adequacy of the proposed approach.