The morphofunctional changes in internal organs and biochemical indicators during acute alcohol intoxication

The study addresses the dynamic morphofunctional changes in internal organs and biochemical indicators in acute alcohol intoxication in rats. After a single intragastric administration of various doses of ethanol, the morphological changes in the brain, liver, and kidneys were evaluated every 60 minutes during six consecutive hours. Data showed that manifestation and severity of pathological changes in morphology of internal organs and values of a number of biochemical indicators depended on alcohol dose and exposure time. Morphological changes that reflected toxic effect of alcohol developed in parallel and were interrelated.