Morphological and expression featuresof ductal pancreatic adenocarcinoma

Pancreatic cancer is one of the most unfavorable malignancies. Approximately 20 % of patients with pancreaticcancer have resectable disease at the time of diagnosis, however the prognosis of the disease in these patientsremains poor, and the overall 5-year survival rate is only 5 %. The evaluation of morphological features, as wellas features of the expression of markers that determine the invasive potential of such neoplasms, can servein the future as a fundamental basis in solving problems concerning prognostic factors in pancreatic cancer.the purpose of the study was to evaluate morphological and immunohistochemical features of pancreaticductal adenocarcinoma. Material and methods. The study included 84 patients with stage T1-4N0-2M0-1pancreatic cancer. The age range was from 37 to 83 years. Surgery was the main treatment option. Morpho-logical examination of surgical specimens showed that the tumor histotype corresponded to pancreatic ductaladenocarcinoma. The preparation of histological specimens and immunohistochemical staining were carried outaccording to standard procedures. results and conclusion. This study allowed us to determine the features oftumor morphology, as well as the features of expression of markers associated with more pronounced invasiveproperties of the tumor. The results of this study may be of interest in terms of their further comparison with theparameters of various forms of progression in pancreatic cancer.