Morphological features of hippocampus pyramidal neurons structure in different age periods of life

Manifestation of age-related cognitive impairment is memory decline, the mechanism of which is associated with the activity of the brain as a whole, but the structures of the hippocampus are of particular importance for the process of memorizing current events. Cognitive impairment can be a result of both physiological involutional changes and a sign of neurodegenerative processes. The aim of the study was to evaluate the structural features of the pyramidal neurons of the hippocampus in individuals of different age groups. Using histological, immunohistochemical and morphometric methods, we examined autopsy material (100 samples) obtained from individuals of both sexes of 4 age categories: 22-35 years (n=16), 36-55(60) years (n=30), 56(60)-74 years (n=26) and 75-90 years (n=28). The results of the study showed the presence of dystrophic changes in the hippocampal neurons in individuals of different age categories with a significant predominance of such cells in individuals of the older (elderly and senile) age groups, as evidenced by statistically significantly (p