Morphological parameters of assessment of the functional state of the thyroid in diffuse toxic state

A histological and immunohistochemical study of 147 thyroid glands removed during surgery from patients with diffuse toxic goiter was carried out. Objective: to study the histological and immunohistochemical changes in the thyroid gland in various forms of diffuse toxic goiter. Histological signs of diffuse toxic goiter are hyperplasia of the lobules, proliferation of follicular epithelium with the formation of intrafollicular epithelium with the formation of intrafollicular epithelium with the formation of intrafollicular papillae, the presence of prismatic or cubic epithelium in the follicles, proliferation of the extrafollicular epithelium, and the proliferation of colonic and extrafollicular epithelium. There are 3 forms of diffuse toxic goiter identified. Immunohistochemical changes in 3 forms of goiter are described. The functional state of the thyroid gland was assessed by the degree of papillary proliferation, the prevalence of lymphoid infiltration and the state of the extrafollicular epithelium.