The morphology of the accidental involution of the thymus at the experimental cancerogenesis

The development of tumors in the body is a powerful factor in the dysfunction of the immune system. The features of involution processes in the thymus in experimental carcinogenesis are due to impaired metabolism in the body as a whole and the production of lymphoid cells with altered functions. The purpose of the study is to summarize data from modern scientific literature and own research on the accidental transformation of the thymus and the reaction of its cellular structures against the background of experimental carcinogenesis with the development of a mammary gland tumor, stress and the combined effect of these factors. Based on the analysis, it was found that dendritic and mast cells of the thymus respond most actively to tumor growth and stress. Morphometric parameters and changes in organ's cytoarchitecture correspond to the phases of the development of accidental involution, which is most pronounced with the combined effect of two factors. A significant role in these processes belongs to biogenic amines and hormones...