Multiplex microdiagnostics based on biorecognition: four generations of biocompatible microfluidic systems

The paper is devoted to microminiaturization problems in bioanalytics. State-of-the-art systems that realize microtechniques of molecular biorecognition are considered. Particular attention is given to microfluidic chip analyzers (MFCA). A comparative analysis of multiplex microdiagnostic techniques is made.