Musculus soleus of rats at physical activity and L-carnitine and creatine phosphate effect

Introduction. The study of the effect of metabolic drugs on the histochemical characteristics of soleus muscle is relevant for solving the problem of providing the training process in Russia with non-doping drugs for safe correction of the consequences of intense physical activity in athletes. Materials and Methods. Dynamic physical activity in rats (n = 24) was simulated by swimming "to the limit" with weighting of 10 % of body weight (20 days, 1 time per day). The experimental animals were divided into four groups (6 animals each): № 1 -control, № 2 - swimming + isotonic NaCl solution, № 3 and № 4 - swimming + L-car-nitine or creatine phosphate 100.0 mg/kg daily intraperitoneally. The object of the study was musculus soleus. Differentiation of muscle fibers was carried out by the intensity of histochemical activity of succinate dehydrogenase (SDG) and alkaline stable adenosine triphosphate (ATP) of myosin. The percentage of muscle fibers was evaluated and their diameter was defined by the direct morphometry. The obtained data were treated statistically by Student's T-test. Results. Swimming of the animals "to the limit" do not affect the ratio of fibers with different phenotypes in the soleus muscle. This indicator is genetically determined and was not modified by L-carnitine and creatine phosphate. Dynamic physical activity promotes the development of hypertrophy of muscle fibers of various types. The investigated medicaments of the metabolic type either do not influence on the formation of exercise-induced hypertrophy (predominantly creatine phosphate) or reduce the intensity of the hypertrophic process (predominantly L-carnitine) under dynamic physical activity. Discussion and Conclusions. The obtained data indicate L-carnitine and creatine phosphate do not have an anabolic effect. Taking into account the relevant data on ability of L-carnitine and creatine phosphate to effectively correct a negative effects of intensive physical exercises, these medicaments can be considered as a medications without anabolic properties for various levels athletes.