Nanocoating in local treatment of burn wounds

The purpose of this study was an experimental study of the effectiveness of the use of bacterial cellulose nanocoating in the local treatment of burn wounds under the control of clinical, planimetric and morphological research methods. The material for the study was a porous microfibril film - a wound coating made of bacterial cellulose with the addition of silver nanoparticles. The object of the study was rabbits of the gray giant breed. The animals underwent modeling of thermal burns of the III degree, after which, on the 5th day, surgical intervention was performed to remove necrotized tissues. The animals were divided into control and experimental groups. In the control group (n = 15), deep burn healing took place independently after necrectomy on the fifth day, without additional medications. In the experimental group (n = 15), a wound coating made of bacterial cellulose was fixed on the wound. The appearance of the wound, the local temperature, the planimetry of the wounds, and the histological picture was examined. When planning the wounds of rabbits of the experimental group, it was noted that by the 28th day the wound area had decreased by 88.9%. It was found that the local application of nanocoating optimizes the wound process to a greater extent in the first phase, optimizes the processes of wound cleansing with subsequent filling of the wound defect with granulation tissue, an earlier start of epithelization of the edges in the regeneration and epithelization phases. The animals of the comparison group did not have fully formed connective tissue at the indicated time.