Non-alcoholic fatty liver disease in patients with different body weights on the background of type 2 diabetes mellitus living in conditions of low and middle mountains

Background. According to various authors, signs of NAFLD at the stage of steatosis in patients with type 2 diabetes are detected in 68.0-87.5% of cases. The relevance of the work is dictated by the lack of knowledge about the features of the course of NAFLD in the Kyrgyz population living in different climatic-geographic regions. The article describes the results of studying the course of NAFLD in individuals with different body weights, suffering from type 2 diabetes mellitus under conditions of high-altitude hypoxia. Aim. To study the features of the course of non-alcoholic fatty liver disease in lean and obese patients suffering from type 2 diabetes mellitus living in the conditions of low mountains and middle mountains of Kyrgyzstan. Materials and methods. An open comparative study of patients with NAFLD (n=366) living in low mountains (height above sea level - 750-800 m) and middle mountains (height above sea level - 2046-2300 m) of Kyrgyzstan was carried out. The average age of the patients was 58±0.69 years. Patients in each region were divided into the following categories: NAFLD and NAFLD in combination with type 2 diabetes. In each category of patients, the lean (BMI≤23) and obese (BMI>23) groups were considered. The level of physical activity (FA), anthropometric parameters and biochemical parameters of blood were determined. The diagnosis of non-alcoholic fatty liver disease was made on the basis of history, laboratory tests, ultrasound examination of the liver, and exclusion of other liver diseases. The results were analyzed using the SPSS 16.0 statistical software package for Windows. A p value function show_eabstract() { $('#eabstract1').hide(); $('#eabstract2').show(); $('#eabstract_expand').hide(); }