Negative symptoms of neuroleptic drugs

Resume: Neuroleptic syndrome is one of the most common complications of taking antipsychotics. The variability of symptoms and side effects from antipsychotics is very high, and in this study we planned to study what complications are most common and in what age range they are more pronounced. This would help physicians who use these drugs the most, predict who is likely to develop neurolepsy, and how to avoid side effects. The pathogenesis of the neuroleptic syndrome is not completely clear, but the pharmacological properties of antipsychotics suggest that it is based on the blockade of dopamine receptors in the nigrostriatal pathway and the associated release of glutamate, leading to an imbalance of neurotransmitters, damage to the basal ganglia and subcortical-thalamic connections, increased synthesis and release of dopamine. For the occurrence of extrapyramidal disorders, a D2 receptor binding level of 75% or more is required.